Hepatoprotective activity and free radical scavenging against induction of CCl4 in an experimental model using dendronaphthya crude extract loaded chitosan nanocarrier

The encapsulation of soft coral Dendronephthya gigantea (SCD) in biopolymers could be attributed to the nature this extract. In present work, chitosan nanoparticles (NCS) as natural biopolymer was prepared using sodium tripolyphosphate (TPP) via ionic gelation method and then encapsulated with SCD. Firstly, GC-MS used determine components More than Forty-components SCD, constituting 89.94%, were identified. Secondly, enhance entrapment efficiency encapsulating degree, polyvinyl alcohol (PVA) cap whole product [email protected] PVA-capped is higher that reached about 96%. Physical advanced tools such TEM, DLS, SEM utilized confirm particle shape for formed nanocomposite, affirming particles originated a spherical no noticeable agglomeration. Besides, PVA found protect produced nanocomposite from agglomeration exhibit latter homogenous structure. After that, rats approximately same weight divided into seven groups treated different formulas evaluate hepatoprotective activity against induction CCl4 nanocomposites loaded Form obtained resultants, it can observed has positive effect on improving values catalase (CA), reduced glutathione (GSH), total antioxidant capacity (TAC) significant decrease malondialdehyde (MDA) values. It also level liver enzymes closely resembles untreated rat group. data proved based exhibited high albumin protein level. Thus, concluded extract (NSC) considered promising formula medicinal domains.